Link to PubMed publications (https://www.ncbi.nlm.nih.gov/pubmed/?term=Appel%20B+zebrafish)
Selected Publication
Mathews, E.S. and Appel, B. (2016) Cholesterol biosynthesis supports myelin gene expression and axon ensheathment through modulation of PI3K/Akt/mTor Signaling. Journal of Neuroscience 36(29):7628-39. PMID: 27445141.
Hudish, L.I., Galati, D.F., Ravanelli, A.M., Pearson, C.G., Huang, P. and Appel, B. (2016) miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development 143(13):2292-304. PMID: 27226318.
Ravanelli AM, Appel B. (2015) Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment. Genes & Development 29:2504-2515. PMCID: PMC4691953.
Kearns CA, Ravanelli AM, Cooper K, Appel B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. Journal of Neuroscience 35(44):14861-71. PMCID: PMC4635133.
Hines JH, Ravanelli AM, Schwindt R, Scott EK, Appel B. (2015) Neuronal activity biases axon selection for myelination in vivo. Nature Neuroscience 18(5):683-9. PMCID: PMC4414883.
Mathews, E.S., Mawdsley, D.J., Walker, M., Hines, J.H., Pozzoli, M. and Appel, B. (2014) Mutation of Hmg-CoA Synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping and myelin gene expression. Journal of Neuroscience 26, 3402-3412. PMCID: PMC3935092.
Hudish, L.I., Blasky, A. and Appel, B. (2013) miR-219 regulates neural precursor differentiation by direct inhibition of apical Par polarity proteins. Developmental Cell 27, 387-398. PMID: 24239515.
Snyder JL, Kearns CA, Appel B (2012) Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. May 3;7:15. PMID: 22554084.
Kucenas S, Wang WD, Knapik EW, Appel B (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J Neurosci. Dec 2;29(48):15187-94. PMID:19955371
Zannino DA, Appel B (2009) Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain. J Neurosci. Feb 25;29(8):2322-33. PMID:19244509
Kucenas, S., Takada, N., Park, H.C., Woodruff, E., Broadie, K. and Appel, B. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature Neuroscience 11, 143-151.
Shin, J., Poling, J., Park, H.C. and Appel, B. (2007) Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development 134, 1911-1920.
Park, H.C., Roberts, R., Shin, J. and Appel, B. (2007) An olig2 reporter gene marks oligodendroycte precursors in postembryonic spinal cord of zebrafish. Developmental Dynamics 236, 3402-3407.
Latimer, A.J. and Appel, B. (2006) Notch signaling regulates midline cell specification and proliferation in zebrafish. Developmental Biology 298, 392-402.
Kirby, B., Takada, N., Latimer, A.J., Shin, J. and Appel, B. (2006) In vivo imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nature Neuroscience 9, 1506-1511.
Park, H.-C., Boyce, J., Shin, J. and Appel, B. (2005) Oligodendrocyte specification in zebrafish requires Notch-regulated cyclin-dependent kinase inhibitor function. Journal of Neuroscience 25, 6836-6844.
Park, H-C., Shin, J. and Appel, B. (2004) Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development 131, 5959-5969.
Park, H.-C. and Appel, B. (2003) Delta-Notch signaling regulates oligodendrocyte specification. Development 130, 3747-3755.
Park, H.-C., Mehta, A., Richardson, J, and Galaxy Sneakers Breathable Breathable Mesh galaxy Fashion Runnning Women Men Shoes amp; CHAQLIN 4 Appel, B. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Developmental Biology 248, 356-368.
