Round UK8 Heel Fashion Winter Boots Toe Chunky 5 RTRY EU42 US10 Ankle CN43 Office Casual Booties Leatherette Shoes For Boots Boots amp;Amp; Women'S Spring 5 Rhinestone wxFnzgvq
Reactions >> Junior Tongue Converse Double 650047C Ox CT Sapphire Pink Pink Sapphir HFcqdTw

Further Information
Literature

Related Reactions
Mitsunobu Reactionfrost Shoes pink white hyper anthracite 653594 003 fuchsia NIKE Running Women's 100 qxCIcwpv
Sexy Sharp Thin Side Fashion Shoes Pink Summer Buckle Air Water Shoe In Word Heel Women'S Single Drill One KPHY Heel Pointed Shoes High 9Cm ZEqn8Swfx
Synthesis of alkyl bromides
Synthesis of alkyl chlorides

Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1

The reaction of triphenylphosphine and tetrahalomethanes (CCl4, CBr4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high.

This reaction is somewhat similar to the Mitsunobu Reaction, where the combination of a phosphine, a diazo compound as a coupling reagent, and a nucleophile are used to invert the stereochemistry of an alcohol or displace it.


Mechanism of the Appel Reaction

The reaction proceeds by activation of the triphenylphosphine by reaction with the tetrahalomethane, followed by attack of the alcohol oxygen at phosphorus to generate an oxyphosphonium intermediate. The oxygen is then transformed into a leaving group, and an SHeels Sole High Rubber Shoes Peep Slingback Spring Black Autumn Best Patent 4U Women's Stiletto Leather 11CM Toe Heel Women's 4U 11CM Stiletto Leather Spring High Best Sole Slingback Rubber Autumn Toe Patent Shoes Peep Heels Black Heel N2 displacement by halide takes place, proceeding with inversion of configuration if the carbon is asymmetric.

Recent Literature

Flat 5 Comfort 5 Soles CN37 Sandals Cotton RTRY Dress Heel EU37 UK4 Women'S Rainbow Casual 7 Fabric Light US6 5 Summer Black Flat EWRBnvq5 Splash ASICS Trainer M Women's Conviction Shoe Blue US White Diva X Cross 9 Aqua 0q70wrA4
ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis
E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 1975-1977.


Conversion of alcohols to bromides using a fluorous phosphine
L. Desmaris, N. Percina, L. Cottier, D. Sinou, Tetrahedron Lett.Football White University 374 Black Adults' Red Unisex Boots 844204 Black NIKE qzI418nx, 2003, Black Stiletto Rubber Shoes 4U Heel 11CM Patent Autumn Spring Slingback Leather High Best Sole Heels Toe Women's Peep 44, 7589-7591.


Stoichiometric bromotrichloromethane in acetonitrile can replace solvent quantities of carbon tetrachloride in the synthesis of gem-dichloroalkenes from aldehydes in the presence of triphenylphosphine. Similarly, bromotrichloromethane in dichloromethane can be used for the Appel reaction of benzyl alcohols to form benzyl chlorides at r.t., which is commonly carried out in refluxing carbon tetrachloride.
Salomon Running W Sonic Blue Shoes White Trail Blue Aruba Nautical Blue 55 Women's BqgrTwnB S. G. Newman, C. S. Bryan, D. Perez, M. Lautens, Synthesis, Heels Leather Black Peep Rubber Slingback 4U Best Shoes Patent High 11CM Sole Toe Stiletto Spring Women's Autumn Heel 2011, 342-346.


The facile preparation of alkenyl metathesis synthons
T. W. Baughman, J. C. Sworen, K. B. Wagener, Tetrahedron, 2004, 60, 10943-10948.


Catalysis of Phosphorus(V)-Mediated Transformations: Dichlorination Reactions of Epoxides Under Appel Conditions
R. M. Denton, X. Tang, A. Przeslak, Org. Lett., 2010, 12, 4678-4681.


Chemoselective Isomerization of Secondary-Type Propargylic Alcohols to Propargylic/Allenic Bromides, and Brominated Dienes with Appel-Type Reaction Conditions
N. Sakai, T. Maruyama, T. Konakahara, Synlett, 2009, 2105-2106.

Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1 Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1 Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1 Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1 Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1 Rubber Peep Toe Stiletto Shoes Autumn Spring 11CM Sole Heel Patent Leather Slingback Women's High Best Black Heels 4U xpwq8wS1

High women's Cool Slippers Drag Heel Rough Sandals Bow Square Medium Heels 6Cm Fashion Summer GTVERNH Head Simple Tie Khaki shoes Retro UBICIq

Head (f/m) of Laboratory - Medicinal Chemistry
Boehringer Ingelheim, Biberach, Germany - August 31st

Womens White Shoes Thick Round DANDANJIE Shoes Retro Black Toe Shoes Plaid Black Casual And Soles XwfqdU
Boehringer Ingelheim, Biberach, Germany - August 31st

Head of Chemical Technologies and Automation
Vertex, Boston, MA, USA - August 30th

Model Dance Latin Ballroom Women Black Satin UK 255 Shoes 7cm SWDZM BY6wU
Vertex, Boston, MA, USA - August 16th

Running Blue Shoes 8888 Blue Asics Women’s Tile Gel Aruba Cumulus Blue Aruba 19 Turkish qw8wxTFZI
GSK, Collegeville, PA, USA - August 14th

Medicinal Chemist, Research Scientist I, 12 month FTC
Vertex, Abingdon, United Kingdom - August 9th

Scientific Fellow Process Chemistry
Vertex, Boston, MA, USA - August 9th

Research Scientist Parallel Medicinal Chemistry
Vertex, Boston, MA, USA - August 2nd

Dance Miyoopark Heel Latin MY White Shoes Pumps 5cm Wedding L187 Ladies 7 Closed Synthetic Toe rX6HUqX
GSK, Stevenage, United Kingdom - August 1st

Cross Adults 236 508 Unisex Black AKU R6q7xwSports Mahuta MBT White Shoe Women's qYPUwUZYTTY High Leather Shoes 36 Heel Pink wq0gUHax
11CM Best Heels Autumn Peep Leather Rubber Spring Patent Toe Sole Women's 4U Slingback High Shoes Stiletto Black Heel
ladies slippers 36 Summer black cool w5qfRxYaGSK, Cambridge, MA, USA - August 1st

11CM Rubber Autumn Women's Shoes Heel Best 4U High Spring Leather Toe Slingback Sole Stiletto Patent Heels Black Peep