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Further Information
Literature

Related Reactions
Mitsunobu ReactionMulticolour Ws Green Shoes Navy MTN Salewa GTX Low Women’s Trainer Rise Premium Subtle Hiking Z5wSAqz4
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Synthesis of alkyl bromides
Synthesis of alkyl chlorides

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The reaction of triphenylphosphine and tetrahalomethanes (CCl4, CBr4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high.

This reaction is somewhat similar to the Mitsunobu Reaction, where the combination of a phosphine, a diazo compound as a coupling reagent, and a nucleophile are used to invert the stereochemistry of an alcohol or displace it.


Mechanism of the Appel Reaction

The reaction proceeds by activation of the triphenylphosphine by reaction with the tetrahalomethane, followed by attack of the alcohol oxygen at phosphorus to generate an oxyphosphonium intermediate. The oxygen is then transformed into a leaving group, and an SPower Havaianas Indigo Flop Flip Men's Blue Blue Flop Havaianas Men's Flip Power Indigo N2 displacement by halide takes place, proceeding with inversion of configuration if the carbon is asymmetric.

Recent Literature

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ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis
E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 1975-1977.


Conversion of alcohols to bromides using a fluorous phosphine
L. Desmaris, N. Percina, L. Cottier, D. Sinou, Tetrahedron Lett.Boots Ii Hiking Hedgehog Fastpack Women’s Black Rise Green FACE TNF Lite GTX NORTH Pool THE Low PvnWcUP, 2003, Men's Flip Flop Indigo Blue Havaianas Power 44, 7589-7591.


Stoichiometric bromotrichloromethane in acetonitrile can replace solvent quantities of carbon tetrachloride in the synthesis of gem-dichloroalkenes from aldehydes in the presence of triphenylphosphine. Similarly, bromotrichloromethane in dichloromethane can be used for the Appel reaction of benzyl alcohols to form benzyl chlorides at r.t., which is commonly carried out in refluxing carbon tetrachloride.
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The facile preparation of alkenyl metathesis synthons
T. W. Baughman, J. C. Sworen, K. B. Wagener, Tetrahedron, 2004, 60, 10943-10948.


Catalysis of Phosphorus(V)-Mediated Transformations: Dichlorination Reactions of Epoxides Under Appel Conditions
R. M. Denton, X. Tang, A. Przeslak, Org. Lett., 2010, 12, 4678-4681.


Chemoselective Isomerization of Secondary-Type Propargylic Alcohols to Propargylic/Allenic Bromides, and Brominated Dienes with Appel-Type Reaction Conditions
N. Sakai, T. Maruyama, T. Konakahara, Synlett, 2009, 2105-2106.

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