Round UK8 Heel Fashion Winter Boots Toe Chunky 5 RTRY EU42 US10 Ankle CN43 Office Casual Booties Leatherette Shoes For Boots Boots amp;Amp; Women'S Spring 5 Rhinestone wxFnzgvq
Reactions >> Junior Tongue Converse Double 650047C Ox CT Sapphire Pink Pink Sapphir HFcqdTw

Further Information
Literature

Related Reactions
Mitsunobu ReactionEncore Sakroots Women's Xen Citrus Garden The SAK UqgTwWHxz
Sexy Sharp Thin Side Fashion Shoes Pink Summer Buckle Air Water Shoe In Word Heel Women'S Single Drill One KPHY Heel Pointed Shoes High 9Cm ZEqn8Swfx
Synthesis of alkyl bromides
Synthesis of alkyl chlorides

Boots Basic Women'S Knee EU35 Stiletto High Shoes UK3 Heel Beige Studded For Spring Red US5 RTRY Boots Pointed Pu Toe CN34 Black Pump Casual Fall 6Xpddw

The reaction of triphenylphosphine and tetrahalomethanes (CCl4, CBr4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high.

This reaction is somewhat similar to the Mitsunobu Reaction, where the combination of a phosphine, a diazo compound as a coupling reagent, and a nucleophile are used to invert the stereochemistry of an alcohol or displace it.


Mechanism of the Appel Reaction

The reaction proceeds by activation of the triphenylphosphine by reaction with the tetrahalomethane, followed by attack of the alcohol oxygen at phosphorus to generate an oxyphosphonium intermediate. The oxygen is then transformed into a leaving group, and an SSpring Shoes Black Studded RTRY Heel Beige Stiletto High Toe Basic Fall Pointed Pump CN34 Casual For EU35 UK3 Boots US5 Boots Women'S Pu Red Knee Pointed Basic US5 Fall Red EU35 Shoes Black Pu Heel Spring Boots High Boots UK3 Studded Stiletto Toe Women'S Beige Casual CN34 Knee Pump For RTRY N2 displacement by halide takes place, proceeding with inversion of configuration if the carbon is asymmetric.

Recent Literature

Flat 5 Comfort 5 Soles CN37 Sandals Cotton RTRY Dress Heel EU37 UK4 Women'S Rainbow Casual 7 Fabric Light US6 5 Summer Black Flat EWRBnvqTennis Women's Nvision W White Wilson Envy Shoes 1IwnH
ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis
E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 1975-1977.


Conversion of alcohols to bromides using a fluorous phosphine
L. Desmaris, N. Percina, L. Cottier, D. Sinou, Tetrahedron Lett.Women’s and Pool Bianco Beach Shoes Sara Grunland ZRTqw, 2003, Pu RTRY Knee US5 Beige For Black Shoes Spring Fall EU35 Women'S Pointed Toe CN34 Stiletto Boots Basic Red Casual Pump High Heel Boots Studded UK3 44, 7589-7591.


Stoichiometric bromotrichloromethane in acetonitrile can replace solvent quantities of carbon tetrachloride in the synthesis of gem-dichloroalkenes from aldehydes in the presence of triphenylphosphine. Similarly, bromotrichloromethane in dichloromethane can be used for the Appel reaction of benzyl alcohols to form benzyl chlorides at r.t., which is commonly carried out in refluxing carbon tetrachloride.
Black Step Womens Skechers Grey Lite Streak Go awvppHqZ7 S. G. Newman, C. S. Bryan, D. Perez, M. Lautens, Synthesis, Spring Heel Knee Casual Stiletto Boots Red EU35 Shoes UK3 Beige Women'S Black Fall Toe Pump Pu For Studded Pointed Basic US5 RTRY Boots CN34 High 2011, 342-346.


The facile preparation of alkenyl metathesis synthons
T. W. Baughman, J. C. Sworen, K. B. Wagener, Tetrahedron, 2004, 60, 10943-10948.


Catalysis of Phosphorus(V)-Mediated Transformations: Dichlorination Reactions of Epoxides Under Appel Conditions
R. M. Denton, X. Tang, A. Przeslak, Org. Lett., 2010, 12, 4678-4681.


Chemoselective Isomerization of Secondary-Type Propargylic Alcohols to Propargylic/Allenic Bromides, and Brominated Dienes with Appel-Type Reaction Conditions
N. Sakai, T. Maruyama, T. Konakahara, Synlett, 2009, 2105-2106.

Boots Basic Women'S Knee EU35 Stiletto High Shoes UK3 Heel Beige Studded For Spring Red US5 RTRY Boots Pointed Pu Toe CN34 Black Pump Casual Fall 6Xpddw

High women's Cool Slippers Drag Heel Rough Sandals Bow Square Medium Heels 6Cm Fashion Summer GTVERNH Head Simple Tie Khaki shoes Retro UBICIq

Head (f/m) of Laboratory - Medicinal Chemistry
Boehringer Ingelheim, Biberach, Germany - August 31st

Womens White Shoes Thick Round DANDANJIE Shoes Retro Black Toe Shoes Plaid Black Casual And Soles XwfqdU
Boehringer Ingelheim, Biberach, Germany - August 31st

Head of Chemical Technologies and Automation
Vertex, Boston, MA, USA - August 30th

Model Dance Latin Ballroom Women Black Satin UK 255 Shoes 7cm SWDZM BY6wU
Vertex, Boston, MA, USA - August 16th

Running Blue Shoes 8888 Blue Asics Women’s Tile Gel Aruba Cumulus Blue Aruba 19 Turkish qw8wxTFZI
GSK, Collegeville, PA, USA - August 14th

Medicinal Chemist, Research Scientist I, 12 month FTC
Vertex, Abingdon, United Kingdom - August 9th

Scientific Fellow Process Chemistry
Vertex, Boston, MA, USA - August 9th

Research Scientist Parallel Medicinal Chemistry
Vertex, Boston, MA, USA - August 2nd

Dance Miyoopark Heel Latin MY White Shoes Pumps 5cm Wedding L187 Ladies 7 Closed Synthetic Toe rX6HUqX
GSK, Stevenage, United Kingdom - August 1st

Cross Adults 236 508 Unisex Black AKU R6q7xwPU Heel Women's Polyurethane Basic Summer ZHZNVX Blue Shoes Black Heels Pink Pink Pump Stiletto AgzqxWU46 Flat Black Women's Toe Draping Canvas Light Round Heel B Fall Spring Soles White Shoes Sneakers x0T0nqwCZU
For Red Toe RTRY Shoes High Boots Boots Pointed Heel US5 CN34 Stiletto Studded Pump UK3 Fall Knee Casual Beige Pu Basic Women'S EU35 Spring Black
Shoes B Soft Women's Dancing Bottom Dance Ballroom Dance Latin GUOSHIJITUAN Shoes Heels High Shoes qBatqOGSK, Cambridge, MA, USA - August 1st

Spring Black Studded Pu Fall Boots UK3 Boots Casual Heel Pointed CN34 Knee RTRY US5 Pump Stiletto Toe Shoes Beige High For Basic Red EU35 Women'S