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Synthesis of alkyl bromides
Synthesis of alkyl chlorides
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The reaction of triphenylphosphine and tetrahalomethanes (CCl4, CBr4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high.
This reaction is somewhat similar to the Mitsunobu Reaction, where the combination of a phosphine, a diazo compound as a coupling reagent, and a nucleophile are used to invert the stereochemistry of an alcohol or displace it.
Mechanism of the Appel Reaction
The reaction proceeds by activation of the triphenylphosphine by reaction with the tetrahalomethane, followed by attack of the alcohol oxygen at phosphorus to generate an oxyphosphonium intermediate. The oxygen is then transformed into a leaving group, and an SPink Trainers Womens New 2017 Navy v2 Balance Fitness X77 Navy Womens 2017 v2 Fitness Balance Pink New X77 Trainers N2 displacement by halide takes place, proceeding with inversion of configuration if the carbon is asymmetric.
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ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis
E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 1975-1977.
Conversion of alcohols to bromides using a fluorous phosphine
L. Desmaris, N. Percina, L. Cottier, D. Sinou, Tetrahedron Lett.Suede Ecru Equinox WOS White Women’s Shoe Black Skate Shoes DVS zR8EZqw, 2003, v2 Navy Pink Balance New X77 Fitness Trainers 2017 Womens 44, 7589-7591.
Stoichiometric bromotrichloromethane in acetonitrile can replace solvent quantities of carbon tetrachloride in the synthesis of gem-dichloroalkenes from aldehydes in the presence of triphenylphosphine. Similarly, bromotrichloromethane in dichloromethane can be used for the Appel reaction of benzyl alcohols to form benzyl chlorides at r.t., which is commonly carried out in refluxing carbon tetrachloride.
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Chemoselective Isomerization of Secondary-Type Propargylic Alcohols to Propargylic/Allenic Bromides, and Brominated Dienes with Appel-Type Reaction Conditions
N. Sakai, T. Maruyama, T. Konakahara, Synlett, 2009, 2105-2106.